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Citing articles via Google Scholar. Niacinamide plays a key role in converting food into energy and helps maintain the normal function of nerves, skin, and the digestive system. Niacinamide is a good source of Vitamin B3 without the flushing effect associated with niacin. It is used in dogs in combination with doxycycline for the treatment of a variety of auto-immune disease. Uses: Niacinamide Vitamin plays a key role in converting food into energy and helps maintain the normal function of nerves, skin, and the digestive system.
It is used in canine medicine in combination with tetracycline for the treatment of a variety of sterile inflammatory skin conditions. One-time Purchase. As such, cats require preformed niacin in the diet [3]. Niacin is used in oxidative-reduction reactions involving catabolism of glucose , fatty acids , ketone bodies, and amino acids. Chronic niacin deficiency results in a wide range of clinical signs from dermatitis and oral mucosa ulceration, to diarrhoea and death.
This condition was originally called black-tongue in dogs and was used as a model to understand and prevent pellagra i. Cats and kittens fed niacin deficient diets develop anorexia, fever, erythema of oral mucosa and tongue with eventual ulceration, weight loss, and death within the weeks. Niacin is prone to degradation with heat processing.
Conditions associated with diuresis e. Patients on chronic haemodialysis are at an increased risk of developing a deficiency. There are no published studies evaluating niacin toxicity in cats. In dogs one study reported bloody diarrhoea in 2 dogs that were fed approximately x the adult requirement, and chronic exposure 11 days resulted in death [10].
At present, an enormous-scale, long-term trial called European Nicotinamide Diabetes Intervention Trial is being conducted to definitely determine whether regular use of niacinamide can prevent diabetes. If a child has just developed diabetes, niacinamide may prolong what is called the honeymoon period. This is in the interval in which the pancreas can still make insulin, and insulin needs are low. A recent study suggests that niacinamide may also improve blood sugar control in type II adult-onset diabetes, but it did not use a double-bind design.
According to several good-size, double-bind studies involving a total of over individuals, a special form of niacin, inositol hexaniacinate, may be able to improve walking distance in intermittent claudication severe leg cramps caused by hardening of the arteries. For example, in one study, individuals were given either placebo or 2 g of inositol hexaniacinate daily.
Over a period of three months, walking distance improved significantly in the treated group. Other treatments that may help intermittent claudication include carnitine and ginko.
This condition includes a response to cold, usually most severely in the hands. The dosage used in he study was 4 g daily, again a dosage high enough for liver inflammation to be a real possibility. Preliminary evidence suggests that niacinamide may be able to reduce symptoms of osteoarthritis. There is some evidence that niacinamide may provide some benefits for those with osteoarthritis. In a double-bind study, 72 individuals with arthritis were given either 3, mg daily of niacinamide in five equal doses or placebo for 12 weeks.
The results showed that treated patients experienced a 20 percent improvement in symptoms, whereas those given placebo worsened by 10 percent.
However, at this dose, liver inflammation is a concern that must be taken seriously. Very weak evidence suggests one of the several forms of niacin may be helpful in bursitis, cataracts, and pregnancy. Therapeutic Uses Niacin was discovered to be the specific chemical that cured black tongue pellagra in dogs fed niacin-deficient diets. Niacin deficiency pellagra causes dermatitis, diarrhea, dementia and death.
Niacinamide has been recommended for the treatment of several disorders in pets, including discoid lupus erythematosus and pemphigus erythematosus in dogs. When combined with tetracycline, niacinamide at a dosage of mg of tetracycline and mg of nacinamide per dog given every eight hours for dogs weighing more than 10 kg has been found to show an excellent response in 25 to 65 percent of cases.
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